Publications by authors named "L Delhaes"
Unlabelled: Intestinal microsporidiosis caused by is an opportunistic infection that especially affects solid organ transplant (SOT) recipients. Management revolves around tapering the immunosuppressive regimen and/or using a specific anti-microsporidia treatment, but only fumagillin has demonstrated efficacy for treatment of this infection. Since fumagillin has been commercially discontinued, nitazoxanide is increasingly being used in this indication.
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- Fungal lung disease includes various infections caused by fungi, particularly from the Aspergillus species, leading to conditions like allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis, influenced by the patient's immune response and the type of fungi.
- The diagnosis of these diseases is complicated by geographic and environmental factors as well as coexisting health issues, with new techniques developing but still facing challenges in speed and accuracy, especially in less developed areas.
- Treatments mainly use antifungal drugs, but drug resistance is becoming a significant problem; however, new antifungal medications and better understanding of the lung mycobiome could pave the way for improved diagnosis and therapy.
Article Synopsis
- Many microorganisms, including bacteria, fungi, and plants, have a protective cell wall that offers strength and protection, especially important for pathogens during host interaction.
- Solid-state NMR has gained attention as a technique to analyze the molecular structure of these cell walls, focusing on the composition of polysaccharides.
- This study explores a method called DREAM to enhance NMR analysis, showcasing its effectiveness in identifying polysaccharide signals in intact fungal cells, and discussing its potential for studying more complex cell surfaces.
Article Synopsis
- The study investigates allergic bronchopulmonary mycoses (ABPM) in patients with cystic fibrosis, focusing on specific IgE responses to five non-Aspergillus molds.
- Researchers analyzed serum samples from 238 patients across several European countries, finding higher levels of specific IgE in these patients compared to healthy controls.
- The findings highlight the need for improved diagnostic tools for ABPM, as several cases were identified using a new scoring system, emphasizing the importance of non-A. fumigatus molds in these conditions.