Publications by authors named "L Delamourd"

Glutaraldehyde hemoglobin polymerization gives too many high polymers, resulting in a too viscous solution. We describe here an alternate method leading to superior results, as compared to the classical one. This method includes a molecular fractionation step using a tangential flow ultrafiltration that secondarily lowers the unpolymerized tetramer's content of a mildly polymerized, pyridoxylated hemoglobin solution (Pyr-Poly Hb).

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The relationship between active transport of lactose via the lactose permease and the protonmotive force has been determined in E. coli cells using either the respiratory chain inhibitor cyanide or protonophores to decrease the protonmotive force progressively. In contradiction with the prediction of the delocalized chemiosmotic theory, two different relationships were obtained depending on the method used.

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A group of two hundred seventy healthy patients aged 20 +/- 2 years endured a progressive physical program during eleven days. The caloric expense was an amount of 4,500 kcal for a ration of 4,200 kcal (+ 33%). When we compared the results of the start and end of this procedure, we found a high loss of weight (68,46 kg instead of 69,34, p less than 0,001), a total cholesterol reduction (4,33 mmol/l instead of 4,75, p less than 0,001), decrease of LDL-cholesterol (2,48 mmol/l instead of 3,15) and of triglycerides (1, 07 mmol/l instead of 0,81, p less than 0,0001); a raise of HDL cholesterol (1,06 to 1,11 mmol/l, p less than 0,01).

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Canrenone (100 mg per day) was given to ten young normotensive subjects during seven days. Plasma--K+ and erythrocytes--K+ (p less than 0,05), diuresis (+ 52%) and natriuresis (+ 70%) increased significantly during this time. Comparison between cations fluxes in erythrocytes before and after giving the drug showed an action on the membranal Na+ - K+ pump.

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