Publications by authors named "L Dekking"
Article Synopsis
- The text discusses immunobridging, a statistical method used to estimate the vaccine's protective effect in humans based on data from animal studies, specifically in relation to the Ebola vaccine regimen Ad26.ZEBOV and MVA-BN-Filo.
- It presents findings that vaccine-induced antibody levels in humans can remain stable for at least 3.8 years, and immunological memory is retained, evidenced by strong responses to booster vaccinations.
- The discussion highlights the potential benefits for humans in utilizing the anamnestic response to combat Ebola virus, considering their slower disease progression compared to non-human primates, which may allow for effective immune response development.
Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.
View Article and Find Full Text PDFSince the original outbreak of the SARS-CoV-2 virus, several rapidly spreading SARS-CoV-2 variants of concern (VOC) have emerged. Here, we show that a single dose of Ad26.COV2.
View Article and Find Full Text PDFThe Marburg virus (MARV) and Sudan virus (SUDV) belong to the filovirus family. The sporadic human outbreaks occur mostly in Africa and are characterized by an aggressive disease course with high mortality. The first case of Marburg virus disease in Guinea in 2021, together with the increased frequency of outbreaks of Ebola virus (EBOV), which is also a filovirus, accelerated the interest in potential prophylactic vaccine solutions against multiple filoviruses.
View Article and Find Full Text PDFSeveral COVID-19 vaccines have recently gained authorization for emergency use. Limited knowledge on duration of immunity and efficacy of these vaccines is currently available. Data on other coronaviruses after natural infection suggest that immunity to SARS-CoV-2 might be short-lived, and preliminary evidence indicates waning antibody titers following SARS-CoV-2 infection.
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