Remodeling the Inflammatory and Immunosuppressive Tumor Microenvironment for Enhancing Antiangiogenic Gene Therapy of Colorectal Cancer.

Fusobacterium nucleatum (Fn), as an intestinal pathogenic bacterium, is closely related to the occurrence, progression, and limited therapeutic efficacy of colorectal cancer (CRC). The presence of Fn within CRC communities induces an inflammatory and immunosuppressive microenvironment while promoting new vessel formation. Therefore, developing novel methods to efficiently eliminate Fn and enhance the therapeutic outcomes against Fn-associated CRC is of great significance.

Scaling-up ecological understanding with remote sensing and causal inference.

Decades of empirical ecological research have focused on understanding ecological dynamics at local scales. Remote sensing products can help to scale-up ecological understanding to support management actions that need to be implemented across large spatial extents. This new avenue for remote sensing applications requires careful consideration of sources of potential bias that can lead to spurious causal relationships.

Synthesising the Relationships Between Food Web Structure and Robustness.

For many decades, ecologists have sought to understand the extent to which species losses lead to secondary extinctions-that is, the additional loss of species that occurs when resources or key interactions are lost (i.e. robustness).

Recall and Appraisal of the Risks, Benefits, and Objectives of Interrupting HIV Treatment in an HIV Cure-Related Study.

The goal of HIV cure research is to either eliminate HIV from the body or durably suppress it in the absence of antiretroviral therapy (ART). This research often requires participants to interrupt ART. However, there are numerous risks associated with ART interruptions and therefore it is critical to understand how people with HIV (PWH) who participate recall the elements of consent, to safeguard their rights and welfare.

Quantifying co-extinctions and ecosystem service vulnerability in coastal ecosystems experiencing climate warming.

Climate change is negatively impacting ecosystems and their contributions to human well-being, known as ecosystem services. Previous research has mainly focused on the direct effects of climate change on species and ecosystem services, leaving a gap in understanding the indirect impacts resulting from changes in species interactions within complex ecosystems. This knowledge gap is significant because the loss of a species in a food web can lead to additional species losses or "co-extinctions," particularly when the species most impacted by climate change are also the species that play critical roles in food web persistence or provide ecosystem services.