Publications by authors named "L Debaisieux"
Despite wide availability of prevention and treatment services, including the ongoing roll-out of pre-exposure prophylaxis (PrEP), the HIV epidemic is not under control in Belgium. Hence, there is a recognized need to improve case finding and early diagnosis to curb the further spread of HIV more effectively. The objective of the present study was to improve insight into the profiles of persons recently infected with HIV-1 and on their prevention trajectory.
View Article and Find Full Text PDFBackground: To assess the prevalence and evolution of transmitted drug resistance (TDR) in Belgium, a total of 3708 baseline human immunodeficiency virus (HIV)-1 sequences from patients diagnosed between 2013 and 2019 were analyzed.
Methods: Protease and reverse-transcriptase HIV-1 sequences were collected from the 7 national Aids Reference Laboratories. Subtype determination and drug resistance scoring were performed using the Stanford HIV Drug Resistance Database.
Introduction: Healthcare professionals have been treating patients with COVID-19 since the pandemic started in early 2020 while also trying to limit disease spread among their coworkers and communities. This study aimed to identify and follow potentially infected healthcare workers in one hospital in order to develop an epidemiological baseline for COVID-19 infection and spread rates in this population.
Materials And Methods: This prospective study was conducted between 1 April and 30 June 2020 at a single Belgian hospital.
Article Synopsis
- - This study analyzed how well different HIV confirmatory assays and rapid tests performed on samples from two groups of patients in Belgium, revealing notable differences in sensitivity rates among tests.
- - In the early-treated patient group (treated within 3 months), 12% of confirmatory tests and 31% of rapid tests returned false-negative results, while the long-term treatment group (over 9 years) had much lower false-negative rates at 2.1% and 4.9%, respectively.
- - The research indicated that longer treatment duration may lead to increased nonreactivity in rapid tests, and it emphasized the need for continued evaluation of these diagnostic tests, especially in patients with undetectable viral loads.
Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, the Belgian AIDS Reference Laboratories collected HIV-1 sequences from all sub-subtype F1-infected patients for whom genotypic drug resistance testing was requested as part of routine clinical follow-up.
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