Publications by authors named "L De la"
Cancer is a complex disease with profound societal and economic impacts, especially in metastatic cases where treatment challenges arise due to the absence of reliable biomarkers and effective therapies. While P21-activated kinases (PAKs) play a key role in cancer progression, their potential as predictive markers for metastasis and therapeutic targets has not been fully explored. We hypothesized that genetic alterations in PAK isoforms could be linked to reduced overall patient survival.
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- Headache disorders are a major cause of disability among young adults, and this study is the first to examine their prevalence among Vietnamese medical students.
- Data were collected from 1,362 participants using structured interviews and diagnostic criteria, revealing that 82.6% experienced headaches in the past year, with specific rates of migraine at 21.8% and tension-type headache (TTH) at 54.0%.
- Female students had a higher likelihood of experiencing migraines, while TTH was more common among older students, indicating varying patterns in headache types based on gender and age.
Background: Mitochondrial dysfunction induces ferroptosis in renal tubular epithelial cells (TECs). Studies have shown that myricanol maintains muscle cell function by enhancing mitochondrial energy metabolism.
Hypothesis: Myricanol delays renal fibrosis by maintaining mitochondrial integrity and inhibiting ferroptosis in TECs.
Regressing the accelerated degradation of skeletal muscle protein is a significant goal for cancer cachexia management. Here, we show that genetic deletion of ameliorates skeletal muscle atrophy in various tumor-bearing mice. ablation represses excessive myoblast mitophagy and effectively suppresses mitochondria meltdown and muscle wastage.
View Article and Find Full Text PDFExposure to pesticides used in rice farming (bentazone, chlorantraniliprole and tebuconazole) affects biochemical biomarkers and hepatic histopathological parameters of hammertoad tadpoles (Boana faber).
Comp Biochem Physiol C Toxicol Pharmacol
September 2024
Article Synopsis
- Pesticides from rice farming can harm non-target organisms, impacting biodiversity, leading researchers to study their presence in river water and their effects on Boana faber tadpoles.
- The study found no major developmental issues in tadpoles but noted increased malondialdehyde (MDA) levels indicating oxidative stress after pesticide exposure, particularly with herbicide BTZ and fungicide TBZ.
- Histological examinations revealed significant changes in the tadpoles, such as inflammation and liver enzyme activity alterations, highlighting the negative impact of rice pesticides on local aquatic ecosystems and biodiversity.