Publications by authors named "L De Sanctis"
To present the technical aspects of contrast-enhanced 4DCT (ce4DCT) simulation for abdominal SBRT. Twenty-two patients underwent two sequential 4DCT scans: one baseline and one contrast-enhanced with personalized delay time () calculated to capture the tumor in the desired contrast phase, based on diagnostic triple-phase CT. The internal target volume (ITV) was delineated on ten contrast phases, and a panel of three experts qualitatively evaluated tumor visibility.
View Article and Find Full Text PDFObjectives: The aim of the present study was to evaluate salivary gland function and oral health status in Osteogenesis imperfecta (OI) children, comparing to a control group, and to investigate the possible influence of bisphosphonate (BP) treatment.
Materials And Methods: Patients aged 8-15 years with any OI molecularly confirmed and gender-matched healthy control were consecutively recruited at the Section of Pediatric Dentistry (Dental School-University of Turin). Comprehensive dental examinations were conducted to evaluate carious lesions, plaque and gingival index, stimulated saliva flow rate, pH, and buffer capacity.
Article Synopsis
- * The study included 118 participants (87 children/adolescents and 31 adults) with PWS, assessing various health metrics, including glucose and cholesterol levels, as well as using a Hyperphagia Questionnaire to measure eating behaviors.
- * Results showed that adults had higher asprosin levels than adolescents, and those with obesity had higher levels than normal-weight individuals, but no significant correlation was found between asprosin and metabolic health indicators;
Rubinstein-Taybi syndrome (RSTS) is a rare autosomal dominant neurodevelopmental disorder linked to haploinsufficiency of CREBBP (RSTS1) and EP300 (RSTS2) genes. Characteristic features often include distinctive facial traits, broad thumbs and toes, short stature, and various degrees of intellectual disability. The clinical presentation of RSTS is notably variable, making it challenging to establish a clear genotype-phenotype correlation, except for specific variants which cause the allelic Menke-Hennekam syndrome.
View Article and Find Full Text PDFArticle Synopsis
- Childhood obesity continues to rise globally despite preventive measures, posing significant risks for cardiovascular and metabolic diseases.
- Early onset of obesity increases long-term exposure to health risks, including severe cardiovascular issues that can occur as early as age 40.
- Recommendations include early detection and treatment of related health conditions, promoting weight loss to reduce risks, and monitoring for long-term health management.