Publications by authors named "L De Propris"

The deep cerebellar nuclei (DCN) have been suggested to play a critical role in sensorimotor learning and some forms of long-term synaptic plasticity observed have been proposed as a possible substrate. However, till now it was not clear whether and how DCN neuron responses manifest long-lasting changes . Here, we have characterized DCN unit responses to tactile stimulation of the facial area in anesthetized mice and evaluated the changes induced by theta-sensory stimulation (TSS), a 4 Hz stimulation pattern that is known to induce plasticity in the cerebellar cortex .

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Article Synopsis
  • Cerebellar plasticity is essential for motor learning, but its mechanisms remain unclear.
  • Researchers devised a protocol to study whisker movement reflex in mice by recording Purkinje cell activity.
  • Training enhanced Purkinje cell activity, leading it to precede behavioral responses, and this change depended on functional synapses between parallel fibers and Purkinje cells.
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In the cerebellar network, a precise relationship between plasticity and neuronal discharge has been predicted. However, the potential generation of persistent changes in Purkinje cell (PC) spike discharge as a consequence of plasticity following natural stimulation patterns has not been clearly determined. Here, we show that facial tactile stimuli organized in theta-patterns can induce stereotyped N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid (GABA-A) receptor-dependent changes in PCs and molecular layer interneurons (MLIs) firing: invariably, all PCs showed a long-lasting increase (Spike-Related Potentiation or SR-P) and MLIs a long-lasting decrease (Spike-Related Suppression or SR-S) in baseline activity and spike response probability.

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This paper presents preliminary results of laboratory tests aimed at evaluating the easibility of the remediation of marine sediments, which are polluted by mercury and petroleum hydrocarbons, dredged at the bay of Augusta (SR, Italy). The treatment is composed of two sequential steps: in the first, a cement-based granular material is produced (based on a high performance concrete approach); then, the volatile and the semi-volatile compounds in the granular material are removed by a thermal desorption step. Treated materials could be reused or put into caissons, according to their mechanical properties and environmental compatibility.

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