Publications by authors named "L De Bus"
Article Synopsis
- The D-PRISM study investigated global practices for diagnosing and treating pneumonia in ICU settings, focusing on community-acquired, hospital-acquired, and ventilator-associated pneumonia across different countries.
- A survey gathered responses from 1,296 ICU clinicians across 72 countries, revealing varied diagnostic processes and a lack of standardized microbiological testing, particularly in lower-income regions.
- Findings indicated that the typical antibiotic treatment duration was 5-7 days, with shorter durations linked to effective antimicrobial stewardship programs in higher-income countries.
Article Synopsis
- A study investigated the effects of carbapenems as initial antibiotics on mortality rates in critically ill patients with bacterial infections, utilizing data from 268 patients across 31 Japanese ICUs.
- Results showed no significant difference in 28-day mortality between patients treated with carbapenems and those who were not (18% vs 16%).
- However, a longer duration of carbapenem use was associated with an increased risk of detecting multidrug-resistant pathogens.
Background: Hospital-acquired bloodstream infections are common in the intensive care unit (ICU) and have a high mortality rate. Patients with cirrhosis are especially susceptible to infections, yet there is a knowledge gap in the epidemiological distinctions in hospital-acquired bloodstream infections between cirrhotic and non-cirrhotic patients in the ICU. It has been suggested that cirrhotic patients, present a trend towards more gram-positive infections, and especially enterococcal infections.
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