Publications by authors named "L De Bolle"
Article Synopsis
- - The study explores the role of different bacteria in chronic airway disease (CAD), focusing on how they might influence inflammation in the lungs, particularly looking for anti-inflammatory species.
- - Using microbiome samples and inflammatory data from patients with CAD, researchers found that the genus Aggregatibacter was more common in patients with lower inflammation levels, linked to reduced inflammatory markers IL-8 and IL-1β.
- - Laboratory tests indicate that Aggregatibacter species have the potential to reduce inflammation in lung cells without harming their viability, suggesting a possible therapeutic role for these bacteria in managing CAD symptoms.
Background: Direct oral anticoagulants (DOACs) can be involved in clinical relevant drug-drug interactions (DDIs) which may compromise safe and effective use. However, assessing the clinical relevance of DDIs with DOACs and managing these interactions optimally, can be challenging in clinical practice.
Aim: To develop a practice-oriented list of potentially clinically relevant DDIs with DOACs with corresponding management plans for which it is important to screen in ambulatory care.
Objectives: Alcohol and medication use are increasingly prevalent in the older population. Concurrent use of alcohol and alcohol-interactive (AI) medication can lead to significant adverse consequences.
Methods: Three reference works were used to create an explicit list of drug substances for which information about the interaction with alcohol was available in at least one of them.
Article Synopsis
- The study addressed the rising issue of alcohol and medication use among older adults, highlighting the risks of combining these substances.
- It involved creating a list of 256 medications known to have interactions with alcohol, using multiple reference works and data from older patients living in the community.
- Findings revealed that nearly half of the older patients consumed alcohol regularly, with a significant percentage using medications that could potentially interact negatively with alcohol.
Coastal areas in north-western Europe have been influenced by elevated nutrient levels starting in the 1960s. Due to efficient measures, both nitrate and phosphate levels decreased since the mid-1980s. The co-occurring declines in nutrient loadings and fish productivity are often presumed to be causally linked.
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