Publications by authors named "L Danziger-Isakov"
Background: Respiratory infections cause a significant amount of morbidity and mortality in pediatric and young adult patients with malignancy. Bronchoscopy with bronchoalveolar lavage (BAL) is frequently utilized in the diagnostic process, but which patients would most benefit is poorly understood.
Methods: A retrospective study from 2013-2022 examined patients with active malignancy who underwent bronchoscopy with BAL.
Influenza is a major cause of morbidity and mortality for pediatric cancer patients. We review important aspects in the management of influenza, including virology, epidemiology, clinical presentation, diagnostic testing, and antiviral treatment. Topics that are addressed include optimal treatment of influenza in children with cancer as well as strategies for prevention.
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- Coccidioidomycosis is a serious fungal infection that can be transmitted through organ transplantation, with a review of cases from 2013 to 2022 revealing significant risks.
- Seven deceased donors transmitted the infection to eight recipients, resulting in a 40% infection rate among organ recipients.
- The study highlights the importance of thorough donor evaluations and antifungal treatment to reduce the high mortality associated with these infections post-transplant.
Transition to Enteral Triazole Antifungal Therapy for Pediatric Invasive Candidiasis: Secondary Analysis of a Multicenter Cohort Study Conducted by the Pediatric Fungal Network.
J Pediatric Infect Dis Soc
November 2024
Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined by clinical progression or worsening. Global treatment response at study completion was success in 66 participants transitioned to enteral therapy.
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- - The study aimed to evaluate the effectiveness of short (<120 days) versus long (>180 days) antiviral prophylaxis for preventing cytomegalovirus (CMV) disease in pediatric liver transplant recipients by analyzing data from the Society of Pediatric Liver Transplantation registry between 2015 and 2019.
- - Among the 199 enrolled participants, shorter prophylaxis resulted in higher occurrences of CMV DNAemia (26.8% vs. 13.8%) and CMV syndrome (18.8% vs. 6.9%) compared to longer prophylaxis, while end-organ disease rates were similar between the two groups.
- - Long prophylaxis was associated with a significantly higher incidence of neutropenia (55