Genetic predisposition to gestational diabetes mellitus in the Kazakh population.

Background And Aims: The purpose of the study was to conduct a comparative analysis of population frequencies of alleles and genotypes of polymorphic variants of genes for impaired insulin synthesis and associated with insulin signal transduction.

Methods: This investigation uses a genomic database of 1800 conditionally healthy individuals of Kazakh ethnicity, who underwent full genome genotyping using OmniChip 2.5-8 Illumina chips of ∼2.

GESTATIONAL DIABETES: PREVALENCE AND RISKS FOR THE MOTHER AND CHILD (REVIEW).

Gestational diabetes mellitus (GDM) is chronic hyperglycemia during gestation in women without previously diagnosed diabetes. This hyperglycemia is caused by impaired glucose tolerance due to pancreatic β-cell dysfunction in the setting of chronic insulin resistance. GDM has been found to affect approximately 4-16.

Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in Kazakhstan: Findings From Large Study.

Type 2 diabetes mellitus (T2DM) is a serious public health problem. A large proportion of patients with T2DM are unaware of their condition. People with undiagnosed T2DM are at a greater risk of developing complications, whereas prediabetes has an elevated risk of becoming T2DM.