[Protective effect on the liver through premedication with radiologically detoxicated endotoxin (Tolerin) in acute myocardial infarction in dogs].

An acute myocardial infarction was produced in experiments in dogs by ligature of the ramus anterior of the left coronary artery. Cell damages in the liver showed electron microscopically 90 and 120 minutes after the begin of the experiment. Destruction or disturbance in the permeability of the liver cells was not or slight developed by pretreatment with radiologically detoxicated endotoxin.

Photodermatoses induced by oral contraceptives.

The pathogenetic role of liver damage in photodermatoses induced by oral contraceptives was investigated. From among 121 cases with photodermatosis, it was in 4 cases of polymorphic light eruption-like dermatosis and in 2 cases of porphyria cutanea tarda that a longterm use of antibaby pills preceded the development of skin disease. Physical and biochemical studies of the liver of the patients suggested that the hepatotoxicity of the estrogen component of oral contraceptives can play a role not only in the pathomechanism of porphyric cases, but also in that of cases occurring with the clinical picture of polymorphic light eruption.