Publications by authors named "L Dalla Via"
Article Synopsis
- High-flow oscillatory ventilation (HFOV) is a vital rescue treatment for infants and children experiencing respiratory failure from various conditions but poses risks for those with congenital heart diseases.
- HFOV operates by delivering small tidal volumes at high frequencies, which can manipulate essential hemodynamic parameters, potentially endangering congenital heart patients.
- Recent studies suggest that HFOV may not significantly impact these hemodynamic factors and can be beneficial for pediatric patients with congenital heart issues, leading to a re-evaluation of its use in this population.
Here, we explored the benzothiopyranoindole scaffold to develop antiproliferative agents with a polypharmacological profile targeting both G-quadruplex (G4)-structures and Topoisomerase (Topo) I enzyme. In a preliminary optimization phase, compound was selected from an in-house collection as a suitable lead for the rational development of a small library of analogs (-). When assayed in NIH's NCI-60 Human Cancer Cell Line In Vitro Screen Program, compound and its demethylated analogue showed significant antiproliferative/cytotoxic activity.
View Article and Find Full Text PDFPreoperative assessment of adults undergoing elective noncardiac surgery: Updated guidelines from the European Society of Anaesthesiology and Intensive Care.
Eur J Anaesthesiol
January 2025
Article Synopsis
- The guidelines from the European Society of Anaesthesiology and Intensive Care Medicine (ESAIC) focus on improving patient assessments before surgery to evaluate risks and enhance the surgical experience.
- A rigorous literature review was conducted, with 17,668 titles initially found, which were narrowed down to 204 relevant studies for a comprehensive analysis using the GRADE methodology.
- Feedback from ESAIC members was gathered on a draft version of the guidelines, which was then refined and officially approved by the Guidelines Committee and ESAIC Board.
Introduction: Obesity is one of the biggest modern health issues worldwide. Owing to the failure of both behavioral and pharmacological measures, the surgical approach has been established as the main conduct to follow, with bariatric surgery being one of the most effective and safe procedures. One of the bases for the optimal analgesic strategy is the use of adjuvants during the perioperative period.
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