Educational Apps and Dog Behavioural Problem Prevention: Associations Between the Zigzag Dog-Training App and Behavioural Problems.

Behavioural problems in dogs are a major welfare concern for both dogs and owners, which can lead to relinquishment or euthanasia. As such, it is important to find ways to minimize the risk of development or severity of problematic behaviour. Such interventions should ideally occur early in the dog's development and need to be widely and easily accessible.

Adolescent girls' explanations of high rates of low mood and anxiety in their population: a co-produced qualitative study.

Background: From early adolescence, girls face greater risk of experiencing low mood and anxiety relative to boys, with recent evidence that this may be worsening. There is a paucity of mental health research that meaningfully progresses understanding of these gender disparities, including that engages adolescent girls' own perspectives, limiting our ability to direct further research and enhance intervention approaches.

Aims: We examined low mood and anxiety from the perspective of adolescent girls, asking: What do adolescent girls perceive to be causing their population's high rates of low mood and anxiety?

Methods: We adopted a co-produced qualitative design, guided by ecological systems theory, conducting focus groups in 2022 with 32 adolescent girls aged 16 to 18 years in England.

Nexus: A versatile console for advanced low-field MRI.

Purpose: To develop a low-cost, high-performance, versatile, open-source console for low-field MRI applications that can integrate a multitude of different auxiliary sensors.

Methods: A new MR console was realized with four transmission and eight reception channels. The interface cards for signal transmission and reception are installed in PCI Express slots, allowing console integration in a commercial PC rack.

ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression.

The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the development of B cell malignancies. The classic form of follicular lymphoma (FL) is a prototypic GC-derived B cell malignancy, characterized by the t(14;18)(q32;q21)IGH::BCL2 translocation and overexpression of antiapoptotic BCL2.

Fine-Tuning Genetic Circuits via Host Context and RBS Modulation.

The choice of organism to host a genetic circuit, the chassis, is often defaulted to model organisms due to their amenability. The chassis-design space has therefore remained underexplored as an engineering variable. In this work, we explored the design space of a genetic toggle switch through variations in nine ribosome binding site compositions and three host contexts, creating 27 circuit variants.