Development of high titer anti-drug antibodies in a Phase 1b/2a infant clesrovimab trial are associated with RSV exposure beyond day 150.

Background: Clesrovimab is a human half-life extended mAb in phase 3 evaluation for the prevention of RSV disease in infants. ADA were observed at late time points in a phase 1b/2a study where clesrovimab was well tolerated with an extended half-life of ∼45 days.

Methods: Serum samples at days 150, 365 and 545 post-dose were assayed for ADA titers.

Long-Term Outcome of Patients with TPO Mutations.

Introduction: Thyroid peroxidase (TPO) deficiency is the most common enzymatic defect causing congenital hypothyroidism (CH). We aimed to characterize the long-term outcome of patients with TPO deficiency.

Methods: Clinical and genetic data were collected retrospectively.

Impact of Sex on Sleep Disorders Across the Lifespan.

Sleep throughout a woman's life impacts her quality of life and medical comorbidities. The prevalence of sleep symptoms and disorders varies throughout a woman's life in association with the reproductive milestones of pregnancy and menopause. Studies have failed to identify a clear sex predominance of sleep disorders in childhood and adolescence.