Publications by authors named "L D Swain"
Background: Alcohol (AC) and nonalcohol-associated cirrhosis (NAC) epidemiology studies are limited by available case definitions. We compared the diagnostic accuracy of previous and newly developed case definitions to identify AC and NAC hospitalizations.
Methods: We randomly selected 700 hospitalizations from the 2008 to 2022 Canadian Discharge Abstract Database with alcohol-associated and cirrhosis-related International Classification of Diseases 10th revision codes.
Drug-induced aseptic meningitis is a rare condition that occurs because of an adverse reaction to medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics. Unlike bacterial or viral meningitis, aseptic meningitis is not caused by an infection, but rather by an inflammatory response. This condition creates a challenge since patients with aseptic meningitis often present with classic clinical meningeal symptoms, including fever, headache, and neck stiffness.
View Article and Find Full Text PDFArticle Synopsis
- In-hospital mortality rates for patients experiencing cardiogenic shock remain high, even with advanced support devices like VA-ECMO and Impella.
- A study analyzed blood samples from 11 patients before and after device implantation, focusing on changes in the plasma proteome using SOMAscan technology.
- The findings indicated that both ECMO and Impella lead to reduced inflammatory markers and increased cell death among inflammatory cells, suggesting that these proteins could be potential targets for new treatments or biomarkers in managing acute myocardial circulatory support (AMCS).
Article Synopsis
- Cardiolipin is crucial for mitochondrial function and is impacted by VA-ECMO, which is used in treating acute myocardial infarction, but its effects on heart damage are not well understood.
- The study found that both human patients requiring VA-ECMO and healthy swine subjected to this treatment showed significantly lower levels of cardiolipin and the enzyme tafazzin, indicating potential detrimental effects on the heart.
- Importantly, VA-ECMO increased heart damage during ischemia/reperfusion, evidenced by a larger infarct size in swine, suggesting that depleting cardiolipin during treatment may worsen myocardial injury.