Publications by authors named "L D Snetselaar"
Background: Individuals who are newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) may choose not to undergo disease-modifying therapies (DMTs) due to concerns about expenses or potential adverse effects. Thus, many individuals will opt for alternative therapies, such as dietary modifications. Among these dietary approaches, the modified Paleolithic elimination diet has shown promise for improving MS-related symptoms; however, restriction of certain food groups can lead to inadequate intake of nutrients.
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- Emerging evidence suggests dietary interventions may improve outcomes for multiple sclerosis (MS), but limited data exists on how they affect functional disability.
- A study pooled data from two 12-week trials to assess the impact of a modified Paleolithic diet (Paleo) on functional disability in MS patients, measuring outcomes with the MS Functional Composite (MSFC).
- The results indicated that while there was no significant overall difference between the Paleo and Control groups, the Paleo group showed reduced functional disability over time, particularly in specific tests, highlighting potential benefits linked to this diet for certain types of MS.
Objectives: This study aimed to examine the combined impact of diet quality and rheumatoid arthritis (RA) on development of cardiovascular and mortality outcomes among postmenopausal women.
Methods: A total of 99,840 women without baseline RA and 10,494 women with baseline RA were prospectively followed for an average of 12.7 years through the Women's Health Initiative.
Article Synopsis
- - This study investigates the relationship between diet quality and the risk of developing rheumatoid arthritis (RA) among postmenopausal women, emphasizing that previous research has yielded inconsistent results around this topic.
- - Conducting a prospective cohort study over an average of 8.1 years, researchers used a food frequency questionnaire to assess the participants' dietary habits and applied the Healthy Eating Index (HEI)-2015 to evaluate overall diet quality.
- - Results showed that a higher diet quality, as indicated by HEI scores, was linked to a reduced risk of developing RA; specifically, higher quartiles of the HEI scores lowered RA incidence by 1%, 10%, and 19% respectively, highlighting the potential benefits of better
Background And Aims: The metabolism of choline (highly present in animal products) can produce trimethylamine N-oxide (TMAO), a metabolite with atherosclerotic effects; however, dietary fiber may suppress this metabolic pathway. This study aimed to develop a dietary pattern predictive of plasma TMAO and choline concentrations using reduced rank regression (RRR) and to evaluate its construct validity.
Methods And Results: Diet and plasma concentrations of choline (μmol/L) and TMAO (μmol/L) were assessed in 1724 post-menopausal women who participated in an ancillary study within the Women's Health Initiative Observational Study (1993-1998).