[Psychopathology of acute organophosphorus compound poisonings].

Under examination there were 65 patients with poisoning with organophosphorus insecticides (thiophos, carbophos, chlorophos). The leading psychotic symptoms in these intoxications were psychovegetative, psychovestibular and hyperkinetic ones, which transformed into each other, as the poisoning progressed. The therapeutic applications of atropine led to development of a drug psychosis resembling the oneiroid syndrome.

[Effect of anticholinesterases on acetylcholinesterase distribution in the human and animal brain (cytochemical study)].

With the use of quantitative histochemistry and cytochemistry methods the localization of acetylcholinesterase in the brain of man and animals in cases of acute poisoning with organophosphorus compounds was studied. In the brain of animals poisoned with chlorophos the activity of the enzyme, according to cytophotometric findings, dropped 2 or 3 times, this drop being more pronounced in the neuropile. In the human brain, the drop of the acetylcholinesterase activity caused by organophosphorus compounds was the most pronounced in the neuropile and the neurons of the cortex, caudate nucleus and hypothalamus.