Health Care Use and Expenditures Associated With Cardiac Rehabilitation Among Eligible Medicare Fee-for-Service Beneficiaries.

Background: Cardiac rehabilitation (CR) can improve cardiovascular health. We identified whether CR participation was associated with fewer subsequent inpatient hospitalizations and emergency department visits and less Medicare and out-of-pocket expenditures, and whether outcomes varied by amount of participation.

Methods: This retrospective study used Medicare fee-for-service claims data, including beneficiaries with a CR-qualifying event in 2016.

Nucleotide-specific RNA conformations and dynamics within ribonucleoprotein condensates.

Ribonucleoprotein (RNP) condensates have distinct physiological and pathological significance, but the structure of RNA within them is not well understood. Using contrast-variation solution X-ray scattering, which discerns only the RNA structures within protein-RNA complexes, alongside ensemble-based structural modeling we characterize the conformational changes of flexible poly-A, poly-U and poly-C single stranded RNA as it interacts with polybasic peptides, eventually forming condensed coacervate mixtures. At high salt concentrations, where macromolecular association is weak, we probe association events that precede the formation of liquid-like droplets.

Social dominance influences individual susceptibility to an evolutionary trap in mosquitofish.

Plastic pollution threatens almost every ecosystem in the world. Critically, many animals consume plastic, in part because plastic particles often look or smell like food. Plastic ingestion is thus an evolutionary trap, a phenomenon that occurs when cues are decoupled from their previously associated high fitness outcomes.

"Telephone Angels" Against Loneliness: Experimental Evaluation of the Effectiveness of Telephone Partnerships with Older Adults.

Loneliness affects many older adults. As part of the "Telephone Angel" project, telephone partnerships between volunteers and older adults affected by loneliness were designed to counteract experiencing loneliness. Volunteers (100 ≤  ≤ 114) and older adults who are (22 ≤  ≤ 45) and who are not (25 ≤  ≤ 71) part of the project were surveyed twice.

Implementation of simultaneous ultraviolet/visible and x-ray absorption spectroscopy with microfluidics.

X-ray spectroscopies are uniquely poised to describe the geometric and electronic structure of metalloenzyme active sites under a wide variety of sample conditions. UV/Vis (ultraviolet/visible) spectroscopy is a similarly well-established technique that can identify and quantify catalytic intermediates. The work described here reports the first simultaneous collection of full in situ UV/Vis and high-energy resolution fluorescence detected x-ray absorption spectra.