[An increase in the incidence of tritium-induced leukoses with the repeated administration of a bacterial lipopolysaccharide].

The incidence of leukoses upon long-term administration of tritium oxide to Wistar rats increased by 15.6% as compared to 2.1% in controls.

[Cytogenetic characteristics of H3 oxide induced myeloid leukemia in Wistar rats].

Frequency and spectrum of chromosomal aberrations were studied in hemopoietic cells of Wistar rats myeloid leukaemia induced by the prolonged exposure to tritium oxide. Differences in quantitative and structural damages of chromosomes were revealed by the cytogenetic assessment of eighteen rats with acute myeloid leukaemia (AML) and six rats with chronic myeloid leukaemia (CML). The most characteristic chromosomal aberrations for AML appeared to be rearrangements in chromosomes 1-3.

[Hematopoietic precursor cells in Wistar rats with acute myeloblastic leukemia].

The studies were performed on Wistar rats with acute myeloblastic leukemia induced by a prolonged administration of tritiated water (370 MBq/kg/day-1; an absorbed dose--25.3 Gy) and by repeated pyrogenal injections. A reduction of the pool of polypotent hemopoietic cells (CFUs) with a simultaneous increase of their proliferative activity and a decline of their ability to self-supporting were observed in the leukemia-bearing animals.

[Disorders of hematopoiesis induced by plutonium-239 dioxide].

A large-dispersed plutonium 239 dioxide intravenously administered to rats in doses of 92.5, 46.3, 23.

[Granulocytopoiesis during the development of radiation injury from prolonged intake of tritium oxide].

During chronic exposure to tritium oxide (a dose rate of 0.125 Gy/day-1, and a cumulative-absorbed dose of 22.1 Gy) different granulocytopoiesis compartments (i.