Publications by authors named "L D Lane"
Tumors can exert a far-reaching influence on the body, triggering systemic responses that contribute to debilitating conditions like cancer cachexia. To characterize the mechanisms underlying tumor-host interactions, we utilized a BioID-based proximity labeling method to identify proteins secreted by Yki adult gut tumors into the bloodstream/hemolymph. Among the major proteins identified are coagulation and immune-responsive factors that contribute to the systemic wasting phenotypes associated with Yki tumors.
View Article and Find Full Text PDFObjective: To determine the incidence and describe the presentation and management of unexpected symptomatic glucocorticoid-induced adrenal suppression (AS) in children and young people aged 0-15 years.
Setting And Design: Surveillance study of symptomatic glucocorticoid (GC)-induced AS with supportive biochemical evidence or presenting as an adrenal crisis, reported via the British Paediatric Surveillance Unit (BPSU) from September 2020 to September 2022.
Results: Over a 25-month period, 190 reports of symptomatic GC-induced AS/adrenal crisis were made, of which 22 were confirmed cases: 18 AS and 4 adrenal crises.
Article Synopsis
- The Human Proteome Project (HPP) aims to identify every protein-coding gene’s isoform and integrate proteomics into studies of human health and disease.
- Major updates include the retirement of neXtProt as the knowledge base, with UniProtKB now serving as the reference proteome, and GENCODE providing the target protein list.
- Recent data shows that 93% of protein-coding genes have been expressed, leaving 1,273 non-expressed proteins, along with the introduction of a new scoring system for functional annotation of proteins.
Article Synopsis
- - Oral Paxlovid is an effective treatment for COVID-19, preventing severe outcomes, but its use remains low among high-risk patients since its introduction in December 2021.
- - A July 2023 survey of 1,430 US adults revealed that 85% had little to no awareness of Paxlovid, with many holding incorrect beliefs about its effectiveness and side effects.
- - The lack of awareness and misunderstandings are particularly prevalent among disadvantaged groups, highlighting the need for improved public communication and outreach as the drug loses government subsidies.
Following burn injury, patients are at increased risk of infection and are often cited as having a high incidence of difficult-to-treat pathogens (DTp). The purpose of this study is to determine the incidence of DTp after burn injury, which factors are associated with their development, and subsequent outcomes. This single-center, retrospective study assessed patients with thermal or inhalation injury who had a positive culture resulting in initiation of treatment (i.
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