Pembrolizumab-induced Sarcoid-like Reactions during Treatment of Metastatic Melanoma.

Pembrolizumab is a programmed cell death protein 1, or PD-1, inhibitor therapy immunotherapy for patients with advanced melanoma. This report discusses a series of documented cases of sarcoid-like reactions associated with this therapy. Three patients with malignant melanoma developed metastatic disease and were treated with pembrolizumab immunotherapy.

An independent assessment of the 7 nomograms for predicting the probability of additional axillary nodal metastases after positive sentinel lymph node biopsy in a cohort of British patients with breast cancer.

Introduction: Axillary lymph node dissection (ALND) is currently the recommended procedure in patients with tumor-positive sentinel lymph node biopsy (SLNB). A significant proportion of patients with positive SLNs will not have any additional metastases in nonsentinel lymph nodes (NSLNs). Predictive nomograms could identify a subgroup of patients with low or high risk of further disease in whom completion ALND can be avoided or recommended.

Primary spindle cell sarcoma of the breast masquerading as necrotizing fasciitis.

Breast sarcomas are rare neoplasms arising from the few epithelial elements of the gland. It represents much <1% of all breast cancer. Of the heterogeneous group of sarcomas, the more common subtypes include spindle cell sarcoma.

Arteritis in the appendix: an unusual cause of right iliac fossa pain.

Many conditions can cause or mimic appendicitis, of which necrotising arteritis remains an unusual cause. Its significance stems from its association with the vasculitides in general. We describe here a 15-year-old-girl with an incidental finding of a focal arteritis in the vasculature of the appendix and with right iliac fossa pain.