Publications by authors named "L D Garrett"
Inversion of chromosome 16 [inv(16)] is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML) and generates the fusion gene , which initiates leukemogenesis. Patients with inv(16) at diagnosis invariably have the rearrangement at relapse, leading to the assumption that is required after leukemic transformation. However, this has yet to be shown experimentally.
View Article and Find Full Text PDFBackground: The area deprivation index (ADI) is a measure of neighborhood disadvantage. It uses census-level information to quantify a person's neighborhood deprivation level based on their address. Recent studies have used ADI to examine the relationship between a patient's address and various health outcomes, including 30-day readmissions.
View Article and Find Full Text PDFArticle Synopsis
- The lncRNA Crossfirre is an X-linked gene that is transcribed opposite to another lncRNA called Firre, and together with Dxz4, they form significant chromatin structures specific to inactive X chromosomes.
- Researchers carried out large-scale knockout studies of Crossfirre, Firre, and Dxz4 to understand their in vivo roles, finding that although these loci have unique epigenetic traits, they are not crucial for X chromosome inactivation processes.
- The study reveals that Crossfirre influences the regulation of autosomal genes, but only in conjunction with Firre, and includes a phenotyping analysis that highlights various knockout and sex-specific outcomes.
Background: The extracellular matrix (ECM) provides structural and functional support for the myocardium, but myocardial infarction (MI) changes the composition of the ECM. One of the chief components of the ECM, hyaluronan (HA), accumulates after MI; however, specific biological actions of HA-particularly at the level of infiltrating immune cells and implications of such interactions on ventricular remodeling-have not been explored.
Goal: Because acute accumulation of HA coincides with macrophage infiltration after MI, we assessed the impact of HA on macrophage function.