[Correction of the lipid composition of the liver plasma membranes during heliotrine intoxication].

Antioxidant properties of yantocine, a preparation derived from Alhagi pseudalhagi Desy, were studied on a model of acute toxic hepatitis induced in random bred young male albino rats (90-100 g). Two experimental models were used: acute geliotrine hepatitis and acute CCl4 hepatitis. Yantocine was added to preparations of damaged plasma membranes (PM) in ascending doses.

Disturbances in oxidative phosphorylation in the liver of rats with heliotrine-induced hepatitis and restoration by phosphatidylcholine and ATP.

Acute hepatitis induced by heliotrine is accompanied by uncoupling of oxidative phosphorylation in liver mitochondria. The rate of oxygen uptake during succinate oxidation increased in all metabolic states, while the respiratory control index decreased by 45% because of the greater increase in the respiration rate in state 4 by comparison with that in state 3. Heliotrine poisoning also halved the rate of oxygen uptake in rat liver homogenates in the presence of ascorbate and tetramethylene-p-phenylenediamine.

[Use of helium-oxygen mixtures in respiratory hypoxia].

Substantiation is given to the approach to the differential prescription of helium-oxygen gas mixtures with a different oxygen concentration for relieving respiratory hypoxia which develops in the obstructive and restrictive types of ventilation abnormalities.