High-grade follicular cell-derived non-anaplastic thyroid carcinomas are rare tumors, particularly in patients under 21, and are more commonly diagnosed in older adults.
A study focused on 15 patients aged 9-20 revealed various classifications of thyroid carcinoma, including poorly differentiated and differentiated high-grade types, with specific genetic alterations noted, especially in the DICER1 and TP53 genes.
Immunohistochemistry tests indicated the presence of BRAF V600E mutations and PTEN alterations, highlighting the molecular complexity of these thyroid cancers in younger populations.