Synthesis, antiulcer and antidepressive activity of 4-(4-halophenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolines.

4-(4-halophenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolines 2a-c have been synthesized by two methods and their biochemical and pharmacological properties have been studied. Biochemical investigations showed that all the compounds are strong inhibitors of DA, NE and 5-HT reuptake, the strongest effect being observed with compound 2b (R = Br). 2a-c exhibited a strong antiulcer activity on an experimental model of stress-induced ulcers with minimal doses (0.

[Correlations between the pharmacological effects of menilon and its concentrations in the plasma and brain of experimental animals].

The authors carried out studies on the preparation menilon in order to establish eventual correlations between some pharmacological and pharmakokinetic indices. For this purpose they examined the activity of menilon in rats and mice during electric shock and hypothermia and determined the concentrations of the preparation in plasma and brain in rats. The obtained results from the pharmacological investigation revealed manifested action against the seizures after electric shock in both groups of animals.

[Determination of the plasma level and excretion to tempidon in man after oral use].

Tempidone is original Bulgarian preparation, synthetized in NIHFI (Zelayskov Bikova). The plasma level of the preparation is determined after single oral administration in doses of 60 and 120 mg and for a period of five days in a dose of 20 mg three times daily per a person. It is shown that tempidone is quickly resorbed and is excreted unchanged mainly in urine.

[Effect of echinopsin and adepren on motor activity in rats].

We have studied the influence of synthesized in NIHFI psychotropic drugs echinopsin and adepren for their locomotor activity on white rats in open field and staircase. Comparative parallel experiments were carried out with psychostimulants and antidepressive drugs utilized in therapeutic practice. We found that echinopsin in low doses increases the locomotor activity and in large doses decreases.