Publications by authors named "L D Conklin"
Article Synopsis
- - The study aimed to overcome barriers in returning individual and aggregate clinical trial data to parents of children in clinical trials, emphasizing the challenges posed by data ownership and confidentiality concerns.
- - The pilot involved a biotech company that obtained ethics approval to allow parents across six countries to request their child's study results through a coordinator, ensuring proper consent and data protection measures were followed.
- - Surveys sent to participating parents revealed a strong interest in receiving as much data as possible, highlighting the demand for transparency in clinical trial outcomes.
Article Synopsis
- Most studies on pediatric inflammatory bowel disease (IBD) largely involve adolescents and suggest that adolescent-onset IBD may not differ significantly from adult-onset IBD, challenging the need for delayed drug access for adolescents.
- Researchers analyzed data from 11 randomized clinical trials, focusing on the treatment responses of 6283 participants (both adolescents and adults) to various biologics for Crohn's disease and ulcerative colitis.
- The findings indicate that treatment responses in adolescents are generally similar to those in adults, supporting the idea that efficacy data from adult studies can be used to approve drugs for adolescents more quickly.
Introduction: Coverage rates for second year of life (2YL) vaccination still lag behind infant vaccination in most settings. We conducted a qualitative baseline study of community barriers and enablers to acceptance of 2YL vaccines in Ghana 4 years after introducing the second dose of the measles-containing vaccine.
Methods: We conducted 26 focus group discussions in 2016 with men and women caregivers from mixed urban, peri-urban, and rural areas, as well as pastoralists, using semistructured topic guides based on the Health Belief Model theory.
Background: Many patients with rare diseases are still lacking a timely diagnosis and approved therapies for their condition despite the tremendous efforts of the research community, biopharmaceutical, medical device industries, and patient support groups. The development of clinical research networks for rare diseases offers a tremendous opportunity for patients and multi-disciplinary teams to collaborate, share expertise, gain better understanding on specific rare diseases, and accelerate clinical research and innovation. Clinical Research Networks have been developed at a national or continental level, but global collaborative efforts to connect them are still lacking.
View Article and Find Full Text PDFBackground: In 2017, the Expanded Programme on Immunization in Ghana opened two container clinics in Accra, which were cargo containers outfitted to deliver immunizations. At each clinic, we assessed performance and clinic acceptance during the first 12 months of implementation.
Methods: We employed a descriptive mixed-method design using monthly administrative immunization data, exit interviews with caregivers of children of <5 years (N = 107), focus group discussions (FGDs) with caregivers (n = 6 FGDs) and nurses (n = 2 FGDs), and in-depth interviews (IDIs) with community leaders (n = 3) and health authorities (n = 3).