Patient-Specific Variability in Interleukin-6 and Myeloperoxidase Responses in Osteoarthritis: Insights from Synthetic Data and Clustering Analysis.

This study investigated the inflammatory responses of fibroblast-like synoviocytes (FLS) isolated from osteoarthritis (OA) patients, stimulated with lipopolysaccharide (LPS) and interleukin-6 (IL-6). Both experimental and synthetic data were utilised to investigate the variability in IL-6 and myeloperoxidase (MPO) production and its implications for OA pathogenesis. Synovial biopsies were obtained from OA patients undergoing joint replacement surgery.

Pyrfume: A window to the world's olfactory data.

Advances in theoretical understanding are frequently unlocked by access to large, diverse experimental datasets. Our understanding of olfactory neuroscience and psychophysics remain years behind the other senses, in part because rich datasets linking olfactory stimuli with their corresponding percepts, behaviors, and neural pathways remain scarce. Here we present a concerted effort to unlock and unify dozens of stimulus-linked olfactory datasets across species and modalities under a unified framework called Pyrfume.

Grow with the flow: Is phenotypic plasticity across hydrodynamic gradients common in seaweeds?

Seaweeds are widely assumed to be phenotypically plastic across hydrodynamic gradients, yet while many marine macroalgae exhibit intraspecific phenotypic variation that correlates with flow, researchers often fail to test whether such variation is due to plasticity or another mechanism, such as local adaptation. In this minireview, we considered mechanisms for sensing flow in seaweeds that could facilitate adaptive phenotypic plasticity across hydrodynamic gradients. We then reviewed the literature from 1900 to 2024 to see how often phenotypic variation and plasticity across hydrodynamic gradients had been observed and demonstrated in different groups of seaweeds.

Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ oligomers.

Background: Alzheimer's disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of soluble amyloid (Aβ) oligomers into the extracellular space is an early feature of AD pathology. This can promote excitotoxicity and microglial activation.

Alcohol, HMGB1, and Innate Immune Signaling in the Brain.

Purpose: Binge drinking (i.e., consuming enough alcohol to achieve a blood ethanol concentration of 80 mg/dL, approximately 4-5 drinks within 2 hours), particularly in early adolescence, can promote progressive increases in alcohol drinking and alcohol-related problems that develop into compulsive use in the chronic relapsing disease, alcohol use disorder (AUD).