Publications by authors named "L D Brix"
Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation.
View Article and Find Full Text PDFObjective: To describe agreement in detection of joint swelling as the mandatory key of the diagnostic algorithm used in rheumatoid arthritis (RA). This was done by comparing clinical examinations, ultrasonography (US), Magnetic Resonance Imaging (MRI) and patient self-evaluation of the joints in the wrist and fingers (metacarpophalangeal joints (MCP) and proximal interphalangeal joints (PIP)) in an early untreated RA cohort.
Methods: 14 patients (8 women and 6 men, mean age ± standard deviation: 54.
Objectives: Early identification of interstitial lung disease (ILD) among patients with rheumatoid arthritis (RA) is a challenge for clinicians. The aim of this study was to evaluate screening algorithms for ILD by comparing the proportion of patients assigned a high-risk profile by three recently proposed models.
Method: We used the four-factor risk score, categorizing patients into high and low risk; the ILD screening criteria, categorizing patients into high, intermediate, and low risk; and the risk score for detection of subclinical RA-ILD, with four different risk categories, on patients with RA followed for 5 years after the RA diagnosis with pulmonary function tests, dyspnoea score, and pulmonary imaging.
Article Synopsis
- The co-chaperone FKBP51, linked to the FKBP5 gene, is a significant psychiatric risk factor for anxiety and depression, particularly affecting the stress response.
- Corticotropin releasing hormone (CRH) is also important in regulating stress, and both FKBP51 and CRH work together to influence the hypothalamic-pituitary-adrenal (HPA) axis.
- Research shows that mice lacking FKBP51 in CRH-expressing neurons display increased stress effects, emphasizing the need for specific research on different cell types to develop personalized approaches for improving stress resilience and mental health.
Article Synopsis
- The study aimed to understand what patients prioritize on the day of their surgery and to showcase the effectiveness of a flash mob research method in a perioperative context.
- Conducted in Danish surgical units, the study involved adult patients who shared their concerns about safety, information, and care, with many feeling their needs were overlooked by staff.
- The findings highlighted the importance of proactive communication from healthcare professionals to better address patient needs and improve the surgical experience.