Publications by authors named "L Cubitt"
Article Synopsis
- Precision medicine relies on understanding genetic variants that cause disease and their effects, exemplified by the von Hippel-Lindau (VHL) gene involved in tumor suppression.
- VHL mutations are linked to specific types of tumors, like clear cell renal cell carcinoma, necessitating refined methods to assess their consequences.
- Researchers developed a technique to analyze nearly all single-nucleotide variants in VHL, leading to the identification of key pathogenic variants and enhancing the ability to classify these genetic changes in clinical settings.
Article Synopsis
- Missions into Deep Space this decade are concerning due to potential health risks from microgravity and galactic cosmic radiation, especially for kidneys.
- Researchers used various biological and clinical analyses on samples from spaceflight-exposed mice, humans, and simulated environments.
- Key findings reveal that spaceflight causes kidney-related issues like increased risk of kidney stones, changes in nephron structure, and damage from radiation exposure.
Article Synopsis
- The study examines how intratumour heterogeneity (ITH) impacts lung cancer evolution, leading to immune evasion and therapy resistance using data from non-small cell lung cancer patients.
- It analyzes RNA and whole-exome sequencing from 354 tumours, revealing significant transcriptomic diversity that contributes to phenotypic variation and influences the selection process during tumour evolution.
- The research identifies key mechanisms like allele-specific expression and RNA-editing enzyme activity that connect the genome and transcriptome, affecting metastasis potential and the overall evolution of lung cancer.
Article Synopsis
- * Out of those tested, 118 had COVID-19, with 94 showing symptoms and only 2 fatalities, revealing high levels of S1-reactive and neutralizing antibodies against the virus.
- * Immune responses varied, particularly with hematological cancer patients showing unique challenges but still managing clinical recovery, highlighting the need for more research on immune durability against different SARS-CoV-2 variants.
