General practice characteristics associated with pay-for-performance in the UK: a systematic review.

Background: The Quality and Outcomes Framework (QOF), a pay-for-performance programme, has been the most widespread quality initiative in National Health Service (NHS) general practice since 2004. It has contributed between 25% and 8% of practices' income during this time, but concerns about its effect on equity have been raised.

Aim: Understand which practice characteristics are associated with QOF performance.

The changing shape of English general practice: a retrospective longitudinal study using national datasets describing trends in organisational structure, workforce and recorded appointments.

Objective: To describe trends in the organisational structure, workforce and recorded appointments by role in English general practice.

Design: Retrospective longitudinal study.

Setting: English general practice.

Intravenous Odatroltide for Acute Ischemic Stroke Within 24 Hours of Onset: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.

Purpose: Odatroltide (LT3001), a novel small synthetic peptide molecule designed to recanalize occluded blood vessels and reduce reperfusion injury, is safe and efficacious in multiple embolic stroke animal models. This study aimed to investigate the safety and tolerability of intravenous administration of odatroltide in patients with acute ischemic stroke within 24 hours of onset.

Patients And Methods: Patients with National Institutes of Health Stroke Scale (NIHSS 4-30) who were untreated with intravenous thrombolysis or endovascular thrombectomy were randomized (2:1) to receive a single dose of odatroltide (0.