Publications by authors named "L Coutte"
Insertion sequences (IS) represent mobile genetic elements that have been shown to be associated with bacterial evolution and adaptation due to their effects on genome plasticity. In , the causative agent of whooping cough, the numerous IS elements induce genomic rearrangements and contribute to the diversity of the global population. Previously, we have shown that the majority of IS-specific endogenous promoters induce the synthesis of alternative transcripts and thereby affect the transcriptional landscape of .
View Article and Find Full Text PDFBacterial-viral co-infections are frequent, but their reciprocal effects are not well understood. Here, we examined the effect Bordetella pertussis infection and the role of pertussis toxin (PT) on influenza A virus (IAV) infection and disease. In C57BL/6J mice, prior nasal administration of virulent B.
View Article and Find Full Text PDFArticle Synopsis
- - The regulation of virulence in bacteria, specifically in the case of whooping cough, relies on two key systems: BvgA/S, which activates virulence genes during the virulent phase, and RisA/K, which represses virulence genes in this phase but activates them in the avirulent phase.
- - Through RNA sequencing and chromatin immunoprecipitation sequencing (ChIPseq), researchers discovered that phosphorylated RisA plays a significant role in regulating many virulence genes, while others are regulated independently from phosphorylation.
- - The study also identified numerous RisA-binding sites, revealing a complex network of gene regulation that includes overlapping binding sites for both RisA and BvgA, emphasizing the intricate relationship between the
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.
Lancet Infect Dis
May 2024
Article Synopsis
- This study investigates the effectiveness and safety of switching from intravenous to oral antibiotics after 5-7 days in patients with low-risk Staphylococcus aureus bloodstream infections.
- Conducted across 31 hospitals in Europe, the trial aimed to determine if early oral therapy could maintain patient safety and reduce complications compared to ongoing intravenous treatment.
- Due to slow participant recruitment, the trial was halted early with 215 participants, and the analysis was adjusted to ensure statistical validity, focusing on whether oral treatment led to acceptable complication rates compared with the traditional intravenous approach.