Publications by authors named "L Cousyn"
Article Synopsis
- Sleep disorders like insomnia and hypersomnia were observed in a patient with anti-NMDAr encephalitis related to an ovarian teratoma.
- Despite initial improvement with immunotherapy, the patient’s condition worsened, revealing severe sleep issues through a 24-hour EEG-polysomnography study.
- Following additional immunotherapy and surgery to remove the teratoma, the patient's clinical symptoms and sleep patterns significantly improved, highlighting the need for more research on sleep in this condition.
Article Synopsis
- This study evaluates how treating vitamin D deficiency impacts seizure frequency in patients with drug-resistant epilepsy.
- The trial involved 88 patients who were split into two groups: one received vitamin D3 supplements, while the other received a placebo over a specified period.
- Results showed no significant difference in seizure frequency reduction after the initial 3 months, but notable improvements occurred later, including a 30% median reduction in seizures and better quality of life scores for those treated with vitamin D.
REM and NREM Sleep Parasomnia in Anti-NMDA Receptor Encephalitis.
Neurol Neuroimmunol Neuroinflamm
September 2024
Objectives: Encephalitis with anti-N-methyl-d-aspartate receptor antibodies (anti-NMDARe) is a rare disorder characterized by cognitive impairment, psychosis, seizures, and abnormal movements. Abnormal behaviors during REM sleep have not been described in anti-NMDARe.
Methods: Patients were monitored by video-polysomnography on a first night followed by multiple sleep latency tests and 18 hours of bed rest.
Article Synopsis
- Heart rate variability (HRV) is a tool to assess the balance of the sympathetic and parasympathetic nervous systems, and may indicate a risk of seizure onset before it happens.
- A study involving 15 patients with drug-resistant focal epilepsy used daily 10-minute EKG recordings to analyze HRV and successfully identified preictal states with a median accuracy (AUC) of 0.75.
- The research suggests using HRV metrics in predict seizure risks could be beneficial if combined with other indicators, like prodromal symptoms and EEG data, to enhance prediction accuracy.