Publications by authors named "L Courtois"
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) shows significant genetic diversity within tumors, complicating targeted treatment approaches and making traditional imaging ineffective for detecting minimal residual disease (MRD).
- A study of 41 patients with resectable HNSCC found that circulating tumor DNA (ctDNA) can serve as a biomarker for assessing tumor heterogeneity and MRD, with notable detection rates at surgery and recurrence.
- The presence of ctDNA shortly after surgery correlated with disease recurrence, providing an early warning about potential relapse, thus supporting its role in post-operative monitoring and precision medicine strategies.
Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor cells. Both dedifferentiated (DD) and well-differentiated (WD) components exhibit MDM2 amplification, however their cellular origin remains elusive.
View Article and Find Full Text PDFUbiquitination plays a crucial role in cellular homeostasis by regulating the degradation, localization, and activity of proteins, ensuring proper cell function and balance. Among E3 ubiquitin ligases, WW domain-containing protein 1 (WWP1) is implicated in cell proliferation, survival, and apoptosis. Notably WWP1 is frequently amplified in breast cancer and associated with poor prognosis.
View Article and Find Full Text PDFSurgical management of chronic sixth cranial nerve palsy: case report and literature review.
Med Hypothesis Discov Innov Ophthalmol
July 2024
Article Synopsis
- Esotropia caused by sixth cranial nerve palsy can greatly affect visual acuity, and if it doesn't improve within 6-10 months, surgery may be needed, with the modified Nishida procedure being a promising option for treatment without splitting muscles.
- A 59-year-old woman with chronic complete sixth nerve palsy underwent the modified Nishida procedure combined with botulinum toxin A (BTA) injection after multiple unsuccessful surgeries, resulting in significant improvement in her condition.
- Post-surgery, the patient experienced better eye alignment, less double vision, and a broader field of vision, showcasing the effectiveness of the modified Nishida procedure for this type of eye disorder.
Article Synopsis
- γδ T cells play a crucial role in immune responses by quickly producing interferon-γ (IFN-γ), especially during the perinatal period when there's an increase in these cells that express CD8αβ heterodimers.
- Their development relies on low T cell receptor signaling, supported by interleukin (IL)-4 and IL-7, which helps regulate their growth.
- Aberrations in IL-7R-STAT5B signaling can lead to an excessive number of these cells in certain diseases, and they are also linked to pediatric cases of acute lymphoblastic leukemia.