Publications by authors named "L Coulon"
A randomized controlled non-inferiority trial of placebo versus macrolide antibiotics for Mycoplasma pneumoniae infection in children with community-acquired pneumonia: trial protocol for the MYTHIC Study.
Trials
October 2024
Article Synopsis
- * The MYTHIC Study is designed as a rigorous trial involving 13 Swiss pediatric centers, comparing macrolide treatment to placebo in children aged 3-17 diagnosed with pneumonia, using precise tests to confirm M. pneumoniae infection.
- * The main goals are to assess the time to stabilize vital signs and determine any changes in patient care within 28 days, with an aim to show that the placebo is not significantly less effective than macrolide treatment in managing this infection.
Water resources play a crucial role in the global water cycle and are affected by human activities and climate change. However, the impacts of hydropower infrastructures on the surface water extent and volume cycle are not well known. We used a multi-satellite approach to quantify the surface water storage variations over the 2000-2020 period and relate these variations to climate-induced and anthropogenic factors over the whole basin.
View Article and Find Full Text PDFChikungunya (CHIK) is a debilitating mosquito-borne disease with an epidemiology and early clinical symptoms similar to those of other arboviruses-triggered diseases such as dengue or Zika. Accurate and rapid diagnosis of CHIK virus (CHIKV) infection is therefore challenging. This international study evaluated the performance of the automated VIDAS anti-CHIKV IgM and IgG assays compared to that of manual competitor IgM and IgG ELISA for the detection of anti-CHIKV IgM and IgG antibodies in 660 patients with suspected CHIKV infection.
View Article and Find Full Text PDFArticle Synopsis
- Ataxia-telangiectasia (A-T) is a complex disorder marked by neurodegeneration, immunodeficiency, and various symptoms including ataxia and increased cancer risk, requiring specialized patient care.
- A variant phenotype of A-T exists, exhibiting some unique features and requiring careful diagnosis to ensure proper management and support.
- A study of 6 patients with both classical and variant A-T highlights their diverse clinical presentations and emphasizes the importance of early recognition for effective treatment and reduction of complications.
Background: A panel of medication management experts previously identified 9 key medication safety issues and high-alert drug classes as representing the most pressing medication-handling issues in health care.
Objective: To develop medication safety pictograms depicting medication safety issues and high-alert drug classes that represent medication-handling risks for health care personnel.
Methods: An iterative design process, including activities such as semiotic analysis, design/redesign, and evaluation, was used to develop medication safety pictograms.