Publications by authors named "L Condorelli"
Multidrug resistance (MDR) due to the overexpression of the P-glycoprotein (P-gp) efflux pump remains a significant challenge in cancer therapy, also in breast cancer. Traditional pharmacological approaches have focused on using inhibitors to modulate P-gp expression and function. Curcumin, a polyphenol derived from Curcuma longa L.
View Article and Find Full Text PDFBackground/objectives: A key role of extracellular vesicles (EVs) is mediating both cell-cell and cell-stroma communication in pathological/physiological conditions. EVs from resistant tumor cells can transport different molecules like P-glycoprotein (P-gp), acting as a shuttle between donor and recipient cells, resulting in a phenotypic change. The aim of our work was to isolate, characterize, and inhibit the release of EVs in two multidrug resistance (MDR) cancer models: MCF-7R (breast cancer cell line) and HL-60R (acute myeloid leukemia cell line).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of ticks as potential vectors in the transmission of contagious agalactia (CA) in sheep and goats, a disease that significantly impacts the dairy industry.
- Researchers used immunohistochemistry to analyze the presence of the pathogen in the salivary glands and ovaries of infected ticks, finding strong evidence of the pathogen localization in these tissues.
- This research marks the first time the pathogen has been shown to cross the tick midgut barrier and infect organs that could facilitate disease spread, indicating the need for further studies to confirm hard ticks' involvement in CA transmission.
In Italy, dairy sheep farming represents a vital agro-industry sector, but it is still challenged by contagious agalactia (CA), which is endemic there, and vaccination is the most economical and sustainable tool for control. This study aimed to evaluate the combined () vaccine ) against the monovalent vaccine in ewes. Twelve primiparous -free ewes were randomly grouped into three equal groups: first, the control group injected with placebo, second, the group vaccinated with the monovalent vaccine, and third, the group vaccinated with combined vaccine, with two S/C doses at 45-day intervals.
View Article and Find Full Text PDFCanine adenovirus type 1 (CAdV-1) is the causative agent of a systemic and potentially fatal viral disease of domestic and wild canids. In Italy, CAdV-1 infection has also been occasionally described in dogs, but information on the epidemiology and its genomic features is still limited. A study was conducted on 291 dogs suspected of infectious gastrointestinal disease.
View Article and Find Full Text PDF