Publications by authors named "L Colombeau"
Complex multicellular organisms are composed of distinct tissues involving specialized cells that can perform specific functions, making such life forms possible. Species are defined by their genomes, and differences between individuals within a given species directly result from variations in their genetic codes. While genetic alterations can give rise to disease-causing acquisitions of distinct cell identities, it is now well-established that biochemical imbalances within a cell can also lead to cellular dysfunction and diseases.
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- Intestinal inflammation alters the composition and metabolism of gut microbiota, but the host's response to these changes is not fully understood.* -
- Mucosal-associated invariant T (MAIT) cells can detect metabolites from riboflavin-producing bacteria that increase during inflammation, promoting tissue repair in the intestines.* -
- Mice without MAIT cells showed higher susceptibility to colitis and related colorectal cancer, highlighting the significance of MAIT cells in responding to gut inflammation through bacterial metabolic pathways.*
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- Age-related microangiopathy (SVD) damages small blood vessels leading to problems in the brain, retina, liver, and kidneys, and is linked to DNA damage as part of the aging process.
- Variants of the TREX1 protein, which play a crucial role in DNA repair, are associated with retinal vasculopathy with cerebral leukoencephalopathy (RVCL), causing improper localization within cells and potential DNA damage.
- Research shows that these TREX1 variants increase vulnerability to DNA damage and are connected to early-onset breast cancer, highlighting a link between abnormal TREX1 activity, aging-related DNA damage, and microvascular disease.
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death referred to as ferroptosis. Identifying where this chemistry takes place in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Whereas genetic approaches have revealed underlying mechanisms of lipid peroxide detoxification, small molecules can provide unparalleled spatiotemporal control of the chemistry at work.
View Article and Find Full Text PDFThis symposium is the 5th PSL (Paris Sciences & Lettres) Chemical Biology meeting (2015, 2016, 2019, 2023, 2024) held at Institut Curie. This initiative originally started at Institut de Chimie des Substances Naturelles (ICSN) in Gif-sur-Yvette, with a strong focus on chemistry. It was then continued at the Institut Curie (2015) covering a larger scope, before becoming the official PSL Chemical Biology meeting.
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