The Brain in Context: A Scoping Review and Concept Definition of Neuro-Informed Policy and Practice.

Background/objectives: Among the developmental sciences, discovery in neuroscience has underpinned research innovations and made a significant contribution to knowledge translation. With the growth of neuroscience discovery, policymakers and practitioner workforces have adopted 'neuro-informed' in decisions targeting the delivery of human, social, and economic wellbeing.

Methods: In this scoping review, we examined the use and conceptualization of neuro-informed policy and practice (NPP) over the last two decades.

Efficacy and tolerability of celastrol and edaravone in the multiple-hit rat model of infantile spasms.

Objective: To test whether anti-inflammatory and antioxidant drugs that inhibit the nuclear factor kappa light chain enhancer of activated B cells (NF-kB), celastrol and edaravone, suppress spasms and improve developmental outcomes in the multiple-hit rat model of refractory infantile spasms (IS) due to structural lesions.

Methods: Postnatal day 3 (PN3) Sprague-Dawley rats were treated according to the multiple-hit IS model protocol. Using a randomized, blinded, vehicle-controlled, dose- and time-response study design, we tested the effects of single celastrol [1, 2, or 4 mg/kg intraperitoneally (i.

Interaction between anthropogenic stressors affects antipredator defense in an intertidal crustacean.

The marine environment is increasingly subject to changes driven by anthropogenic stressors which may alter species' key behaviors and impact phenotypic plasticity. Such stressors rarely occur in isolation, yet our understanding of how simultaneous stresses affect marine organisms is limited. Here, we study the combined impacts of a major global stressor, temperature increase, and a local stressor, anthropogenic noise, upon key defensive traits of the shore crab, .

Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography.

Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators.