Publications by authors named "L Colangelo"
Alkaline phosphatase (ALP) is abundantly represented in nature, being fundamental for a number of processes. In addition to its fundamental function in skeletal mineralization, its roles in the pathogenesis of other diseases are being explored. The measurement of total ALP activity in serum or in plasma is a useful biomarker in clinical practice.
View Article and Find Full Text PDFA 58-yr-old woman presented to our mineral metabolism center, complaining of localized and continuous pain, which worsened with movements, and weakness of the right foot. The patient reported having had a fracture of the fifth metatarsal bone of the right foot about 4 mo ago. She was initially treated with a cast that she did not tolerate and then with an orthopedic brace.
View Article and Find Full Text PDFHepatic steatosis is a central phenotype in multi-system metabolic dysfunction and is increasing in parallel with the obesity pandemic. We use a translational approach integrating clinical phenotyping and outcomes, circulating proteomics, and tissue transcriptomics to identify dynamic, functional biomarkers of hepatic steatosis. Using multi-modality imaging and broad proteomic profiling, we identify proteins implicated in the progression of hepatic steatosis that are largely encoded by genes enriched at the transcriptional level in the human liver.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed how different levels of psychosocial stress impact the risk of cardiovascular disease (CVD) over time, using data from the Multi-Ethnic Study of Atherosclerosis (MESA) involving over 6,300 adults.
- Researchers found five distinct subgroups of psychosocial stress based on self-reported data, with 'high discrimination' being linked to a significantly increased risk of CVD events, even after adjusting for other health factors.
- Social support, neighborhood cohesion, and physical activity did not significantly alter the relationship between psychosocial stress and CVD risk, indicating that high levels of discrimination and chronic stress are critical factors for cardiovascular health outcomes.
Background: There are few and controversial results on 24,25(OH)D and FGF23 acute changes following supplementation with cholecalciferol.
Methods: Twenty-seven subjects with 25(OH)D < 30 ng/mL were randomized into three groups to receive a single oral dose of 25,000 I.U.