Publications by authors named "L Clayton Dymond"
Article Synopsis
- - The study investigates the effectiveness of immunotherapy for gastrointestinal stromal tumors (GISTs) using humanized mouse models to better understand the tumor environment.
- - Researchers utilized a cancer vascular targeting peptide (VTP) to deliver the LIGHT protein into GIST tumors, which enhanced blood vessel function and oxygen levels, leading to an increase in human effector T cells within the tumors.
- - The findings suggest that targeting tumor blood vessels and promoting immune responses could improve treatment outcomes for GIST patients, especially since certain structures associated with better prognosis were observed in treated tumors.
Background: Lung cancer is the leading cause of cancer-related death due in large part to our inability to diagnose it at an early and potentially curable stage. Screening for lung cancer via low dose computed tomographic (LDCT) imaging has been demonstrated to improve mortality but also results in a high rate of false positive tests. The identification and application of non-invasive molecular biomarkers that improve the performance of CT imaging for the detection of lung cancer in high risk individuals would aid in clinical decision-making, eliminate the need for unnecessary LDCT follow-up, and further refine the screening criteria for an already large high-risk population.
View Article and Find Full Text PDFBackground: Tilapia are commercially important tropical fish which, like many teleosts, have anatomically discrete islet organs called Brockmann bodies. When transplanted into diabetic nude mice, tilapia islets provide long-term normoglycemia and mammalian-like glucose tolerance profiles.
Methods: Using site-directed mutagenesis and linker ligation we have "humanized" the tilapia insulin gene so that it codes for [desThrB30] human insulin while maintaining the tilapia regulatory sequences.
We determined serum Na+ and Cl- results using Technicon's Flame IV-Auto Analyzer II (FLIV/AAII) system and Kodak's Ektachem 400 clinical analyzer. Our objective was to determine whether Na+ and Cl- results from these analyzers were sufficiently similar to report to clinicians without reference to the system used for the determination. Method precision of the two systems for Na+ results was comparable; whereas Ektachem 400 Cl- results were more imprecise than those determined using the FLIV/AAII, Ektachem Na+ results showed lower correlation with the FLIV/AAII (r = 0.
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