Publications by authors named "L Clayton"
Article Synopsis
- Rare inherited diseases caused by mutations in copper transporters (CTR1) lead to copper deficiency, which can cause severe neurological issues like seizures and neurodegeneration in infants.
- The study explores how neuronal cells react to copper deficiency using various genetic model systems, showing that the absence of CTR1 leads to disrupted cellular functions and a shift toward glycolysis.
- Key findings reveal that the activation of the mTORC1-S6K signaling pathway serves as a protective mechanism to enhance protein synthesis in response to copper deficiency, helping to mitigate some of the detrimental effects on neurons.
Article Synopsis
- Rituximab is an effective monoclonal antibody treatment for CD20-positive lymphomas, but lymphoma patients are at higher risk for severe COVID-19 due to their age and comorbidities.
- A study of 28 lymphoma patients receiving rituximab showed reduced levels of antibody responses (IgG and IgA) to the COVID-19 vaccine compared to healthy individuals, indicating a potential challenge for vaccine effectiveness.
- However, the T-cell responses in these patients were comparable to those of healthy controls, suggesting that future vaccines can be optimized to enhance T-cell immunity for better protection in patients undergoing B-cell depleting therapies.
Article Synopsis
- - This study investigates the incidence of delayed intracranial hemorrhage (ICH) in older patients (65+) who suffered head trauma and were on anticoagulant medications, noting that delayed ICH rates post-injury range widely in existing literature.
- - Conducted across two emergency departments with 3,425 enrolled patients, the findings showed a very low incidence of delayed ICH at 0.4%, and no significant difference in rates between patients on anticoagulants and those not on them.
- - The results suggest that delayed ICH is uncommon in this population, which could influence clinical decision-making and management strategies for geriatric patients with blunt head trauma.
Alcohol use is associated with intracranial hemorrhage in older emergency department head trauma patients.
J Am Coll Emerg Physicians Open
August 2024
Objectives: Falls are common in adults aged 65 years and older and are the leading cause of traumatic brain injuries in this age group. Alcohol use may increase the risk of falls as well as the severity of resultant injuries. The aim of this study was to examine the association between self-reported alcohol use and the prevalence of intracranial hemorrhage (ICH) in this patient group.
View Article and Find Full Text PDFIntroduction: Teledermatology, defined as the use of remote imaging technologies to provide dermatologic healthcare services to individuals in a distant setting, has grown considerably in popularity since its widespread implementation during the COVID-19 pandemic. Teledermoscopy employs a smartphone dermatoscope attachment paired with a smartphone camera to visualize colors and microstructures within the epidermis and superficial dermis that cannot be seen with the naked eye ABCD criteria alone.
Methods: Our retrospective observational cohort and case-control study evaluated the utility of loaning a smartphone dermatoscope attachment to patients for remote triage of self-selected lesions of concern for skin cancer.