Publications by authors named "L Cistarelli"

Intracellular accumulation of tau protein is a hallmark of Alzheimer's Disease and Progressive Supranuclear Palsy, as well as other neurodegenerative disorders collectively known as tauopathies. Despite our increasing understanding of the mechanisms leading to the initiation and progression of tau pathology, the field still lacks appropriate disease models to facilitate drug discovery. Here, we established a novel and modulatable seeding-based neuronal model of full-length 4R tau accumulation using humanized mouse cortical neurons and seeds from P301S human tau transgenic animals.

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Trace Amine-Associated Receptor 1 (TAAR1) is a potential target for the treatment of depression and other CNS disorders. However, the precise functional roles of TAAR1 to the actions of clinically used antidepressants remains unclear. Herein, we addressed these issues employing the TAAR1 agonist, o-phenyl-iodotyramine (o-PIT), together with TAAR1-knockout (KO) mice.

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Article Synopsis
  • "Ecstasy" (MDMA) has prosocial effects but also poses risks due to recreational use and has been found to interact with trace amine-1 receptors (TA(1)Rs), which influence dopamine transmission.
  • In experiments with mice, those lacking TA(1)Rs (TA(1)-KO) showed increased dopamine and serotonin release from MDMA compared to normal mice (WT), indicating TA(1)Rs help regulate these neurochemical actions.
  • The study suggests that TA(1)Rs inhibit dopamine and serotonin release, and MDMA may auto-inhibit itself by activating these receptors, offering important insights into the drug's effects in humans.
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The novel benzopyranopyrrolidine, S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], is a preferential antagonist of cloned human D(3) versus D(2L) and D(2S) receptors. In mice, S33138 (0.04-2.

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Though dopaminergic mechanisms modulate cholinergic transmission and cognitive function, the significance of specific receptor subtypes remains uncertain. Here, we examined the roles of dopamine D(3) versus D(2) receptors. By analogy with tacrine (0.

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