Publications by authors named "L Cipolla"
A novel starch-based ether bearing cinnamyl functionalities, conferring photo-crosslinking properties, is synthesised by reaction with cinnamyl chloride in the presence of sodium hydroxide. Natural yuca was selected as a sustainable source of starch. Three different molar equivalents of reagents are used, affording starch-cinnamyl ethers with different degrees of substitution, ranging from 0.
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- * A dominant prevalence of the 1-type strain was found, with the identification of two harmful international variants (1-UK and 1-DK) and a local variant (1-ST1319).
- * The findings highlight the need for ongoing genomic surveillance to address the rise of invasive infections and monitor the spread of virulent strains across South America.
Human osteocalcin (OC) undergoes reversible, vitamin K-dependent γ-carboxylation at three glutamic acid residues, modulating its release from bones and its hormonal roles. A complete understanding of OC roles and structure-activity relationships is still lacking, as only uncarboxylated and few differently carboxylated variants have been considered so far. To fill this lack of knowledge, a comprehensive experimental and computational investigation of the structural properties and calcium-binding activity of all the OC variants is reported here.
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- HDAC6 is a key player in gene regulation and chromatin dynamics, making it an important focus in cancer research, particularly regarding its role in the stabilization of the P300 protein.* -
- Inactivating HDAC6 using an inhibitor or gene editing techniques results in increased chromatin accessibility and changes in gene expression related to cancer cell behaviors like proliferation and migration.* -
- The study suggests that instead of targeting HDAC6 directly, future cancer therapies could focus on its interaction with P300, highlighting new pathways for targeted treatment based on epigenetic changes.*
Human listeriosis is an infectious disease caused by Listeria monocytogenes. The invasive form of this disease leads to a high rate of hospitalizations and fatality. The main mode of transmission is through contaminated ready-to-eat foods such as dairy, vegetables and meat products.
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