Publications by authors named "L Ciccone"

Article Synopsis
  • A new panel of metal-betaine-bistriflimide complexes (like Mg, Ca, Zn, Cu, and Ni) has been created with high purity and yield.
  • In addition, related metal bistriflimide salts were synthesized and analyzed using similar techniques.
  • This study is the first thorough exploration of the physical and chemical properties of these metal systems, revealing how factors like metal cations and betaine coordination influence solubility, stability, and electrochemical characteristics, which are crucial for potential applications.
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Article Synopsis
  • * The paper reviews the latest transthyretin stabilizers, discussing their effectiveness and providing crystallographic data to explain how they work in the body.
  • * Additionally, it highlights new findings that challenge existing design principles for developing new stabilizers, aiming to guide future research and improve treatment options.
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Transthyretin (TTR) is a tetrameric protein traditionally recognized for its role in transporting thyroxine and retinol. Recent research has highlighted the potential neuroprotective functions of TTR in the setting of Alzheimer's disease (AD), which is the most common form of dementia and is caused by the deposition of amyloid beta (Aβ) and the resulting cytotoxic effects. This paper explores the mechanisms of TTR protective action, including its interaction with Aβ to prevent fibril formation and promote Aβ clearance from the brain.

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Multinuclear complexes are metal compounds featured by adjacent bound metal centers that can lead to unconventional reactivity. Some ML-type paddlewheel dinuclear complexes with monoanionic bridging ligands feature promising properties, including therapeutic ones. Molybdenum has been studied for the formation of multiple-bonded M compounds due to their unique scaffold, redox, and spectroscopic properties as well as for applications in several fields including catalysis and biology.

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Article Synopsis
  • The use of external beam radiotherapy (EBRT) for thyroid cancer treatment is debated because there isn't a lot of strong data.
  • Some studies suggest that EBRT can help people with high-risk cases of thyroid cancer when it's used with surgery and chemotherapy.
  • Newer treatments like proton therapy and Boron Neutron Capture Therapy (BNCT) could be helpful, but more research is needed to understand how they work best.
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