The development of perfusable and multiscale vascular networks remains one of the largest challenges in tissue engineering. As such, there is a need for the creation of customizable and facile methods to produce robustly vascularized constructs. In this study, secondarily crosslinkable (clickable) poly(ethylene glycol)-norbornene (PEGNB) microbeads were produced and evaluated for their ability to sequentially support suspension bioprinting and microvascular self-assembly towards the aim of engineering hierarchical vasculature.
View Article and Find Full Text PDFMaintaining the optimal microclimate in broiler houses is crucial for bird productivity, yet enabling efficient temperature control remains a significant challenge. This study developed and validated a computational fluid dynamics (CFD) model to predict temporal changes in indoor air temperature in response to variable ventilation operations in a commercial broiler house. The model accurately simulated air velocity and airflow distribution for different numbers of tunnel fans in operation, with air-velocity errors ranging from -0.
View Article and Find Full Text PDFThe UK National Institute for Health and Care Excellence (NICE) guidance for the treatment of depression is widely followed and has international influence. According to these guidelines, antidepressant medications are recommended for moderate to severe depression. Nonetheless, antidepressants are increasingly prescribed, including for cases of subthreshold and mild depression.
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