Publications by authors named "L Chico-Sordo"
The study of microRNAs (miRNAs) has emerged in recent decades as a key approach to understanding the pathophysiology of many diseases, exploring their potential role as biomarkers, and testing their use as future treatments. Not only have neurological, cardiovascular diseases, or cancer benefited from this research but also infertility. Female infertility, as a disease, involves alterations at multiple levels, such as ovarian and uterine alterations.
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- The study investigates the role of long non-coding telomeric repeat-containing RNAs as potential biomarkers for idiopathic male infertility, focusing on two groups of men: those with normal sperm (normozoospermic) and those with reduced sperm quality (oligoasthenozoospermic).
- Findings reveal that oligoasthenozoospermic men not only had worse sperm quality but also produced embryos with lower inner-cell-mass quality, and they exhibited shorter telomeres and more sperm with abnormal telomeric structures compared to normozoospermic men.
- A positive correlation was noted between telomeric RNA levels and sperm motility in normozoospermic men, suggesting
Article Synopsis
- The diagnosis of endometriosis often occurs late due to reliance on invasive procedures like laparoscopy; researchers are exploring microRNAs as potential early biomarkers.
- A study involving 159 women found that serum levels of miR-30c-5p were significantly higher in those with endometriosis compared to healthy individuals, suggesting its effectiveness in diagnosis.
- The results indicate miR-30c-5p could serve as a minimally invasive biomarker for endometriosis, showing associations with pathways linked to cancer and neuronal processes.
Article Synopsis
- Telomeres are protective structures at the ends of chromosomes, initially described in the 1930s, which were linked to the limits of cell division and aging by Alexey M. Olovnikov in the 1970s.
- Telomere shortening affects life expectancy and is countered by telomerase, an enzyme found in cancer and stem cells, while their dynamics differ between male and female gametes.
- Short telomere lengths in ovarian cells can lead to reduced fertility and higher rates of embryo abnormalities, prompting interest in telomere lengthening strategies and the impact of lifestyle factors on fertility.
Article Synopsis
- Women experiencing ovarian failure (OF) often show short telomeres and low telomerase activity, suggesting a link between telomere health and fertility issues; using sexual steroids to reactivate telomerase might improve IVF outcomes.
- A double-blind study with patients having diminished ovarian reserve showed that those treated with Danazol for 3 months had changes in telomere dynamics, although overall telomere length remained similar.
- Treatment with Danazol improved the maturity rate of oocytes in later ovarian stimulation cycles, indicating potential benefits for IVF success, but further studies are necessary to validate these findings.