Publications by authors named "L Chevallier"
Article Synopsis
- Hypohidrotic ectodermal dysplasia is a genetic condition resulting in sparse hair, missing or malformed teeth, and issues with sweat glands, caused by mutations in an X-chromosome gene.
- A male cat was studied that displayed symptoms like complete undercoat absence and abnormal teeth, leading to a genetic examination.
- Whole-genome sequencing uncovered a specific gene variant linked to this condition, matching a known human variant, marking this as the first report of this disorder in cats.
Article Synopsis
- This report highlights a rare case of cutaneous mast cell tumors in an 11-year-old Prim'Holstein cow who had multiple skin nodules for five months.
- Diagnosis was confirmed through cytologic and histologic analyses, along with the detection of KIT expression in the neoplastic mast cells.
- Although the cow showed a partial response to corticosteroids, euthanasia was chosen ultimately, with post-mortem examinations revealing no metastases in key organs.
New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex.
Pharmaceuticals (Basel)
December 2023
The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines are reported here in six steps starting from various halogeno-quinazoline-2,4-(1,3)-diones or substituted anilines. The antiproliferative activities of the products were determined in vitro against a panel of breast (MCF-7 and MDA-MB-231), human adherent cervical (HeLa and SiHa), and ovarian (A2780) cell lines. Disubstituted 6- and 7-phenyl-bis(3-dimethylaminopropyl)aminomethylphenyl-quinazolines , , and displayed the most interesting antiproliferative activities against six human cancer cell lines.
View Article and Find Full Text PDFIntroduction: Endometriosis is a female disease that affects 5-10% of women of childbearing age, with predominantly pelvic manifestations. It is currently declared as a public health priority in France. Thoracic endometriosis syndrome (TES) is the most common extra-pelvic manifestation.
View Article and Find Full Text PDFIntroduction: The organization of patient transfer from conventional hospital to hospitalization at home (HAH) is not well known.
Purpose Of Research: Our study aims to describe this organization by identifying the key professionals of the pathways and the incentives and obstacles to the continuity of care.
Results: Patient transfer from conventional hospital to HAH is a period of strong tension between all health care professionals and the organization of discharge is not sufficiently anticipated by hospital prescribers.