Publications by authors named "L Cher"
Background And Aims: Acute variceal bleeding (AVB) is a major complication in patients with cirrhosis. Using a nationwide AVB audit, we performed a nested cohort study to determine whether full adherence to the AVB quality indicator (QI) improves clinical outcomes in patients with cirrhosis and AVB.
Approach And Results: We assessed real-world adherence to AVB QI among patients with cirrhosis admitted for AVB in all public hospitals in Singapore between January 2015 and December 2020.
Antibody drug conjugates for glioblastoma: current progress towards clinical use.
Expert Opin Biol Ther
December 2023
Article Synopsis
- Antibody drug conjugates (ADCs) are effective cancer treatments that combine targeted delivery with potent drugs, and this review focuses on their application in brain tumors.
- The review highlights different ADC classes tested in primary brain tumors, discusses major clinical trials, and outlines both their successes and limitations in the context of drug development.
- ADC development for brain tumors has evolved through two main phases, with insights from past trials guiding future strategies that consider the unique biology of these tumors.
Article Synopsis
- Limited progress in glioblastoma treatment is attributed to the poor correlation between preclinical data and clinical trial outcomes, indicating a barrier to effective drug development.
- A systematic review of phase I trials from 2006-2019 revealed that most trials had preclinical data available, but overall correlations in efficacy were weak; however, drugs tested in multiple models showed better median response rates.
- The findings suggest that existing preclinical models may overestimate drug effectiveness; therefore, improving these models or using multiple distinct in vivo models is crucial for developing new anti-glioblastoma therapies.
Medulloblastoma in adult patients is a rare condition with limited contemporary demographic and treatment outcome data available in an Australian population. We conducted a retrospective review of patterns of care and outcomes of adult patients diagnosed with medulloblastoma treated at major neuro-oncology centres across Australia between January 2010 and December 2019. A total of 80 patients were identified and the median follow-up after diagnosis was 59.
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