Publications by authors named "L Chazalviel"
Article Synopsis
- The study focused on understanding the tumor microenvironment (TME) of brain metastases (BM) from lung cancer, specifically looking at factors like hypoxia and redox state, which impact tumor growth and treatment resistance.
- In vitro experiments showed that lung cancer cells increased certain proteins in response to low oxygen levels (hypoxia), indicating metabolic and oxidative stress changes in the tumor tissue.
- Imaging techniques, particularly [Cu][Cu(ATSM)] PET, revealed significant differences in hypoxia levels and protein expressions between cortical and striatal brain metastases, highlighting the importance of this imaging method in tailoring treatment approaches based on tumor characteristics.
Purpose: Radiation therapy for brain tumors increases patient survival. Nonetheless, side effects are increasingly reported such as cognitive deficits and fatigue. The etiology of fatigue remains poorly described.
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- The study investigates acute ischemic stroke, focusing on distinguishing between the ischemic core and the potentially salvageable penumbra using a new MRI technique for measuring brain oxygen levels (S O -MRI).
- The research found a strong correlation between S O -MRI signals and PET imaging of hypoxic tissues, indicating that S O -MRI can effectively identify areas at risk in stroke cases.
- Results showed that S O -MRI could not only detect hypoxia but also predict the final extent of brain lesions, suggesting its potential as a tool for better patient treatment strategies in acute stroke scenarios.
Background: Cerebrospinal fluid (CSF) diversion by shunts is the most common surgical treatment for hydrocephalus. Though effective, shunts are associated with risk of dysfunction leading to multiple surgical revisions, affecting patient quality-of-life and incurring high healthcare costs. There is a need for ambulatory monitoring systems for life-long assessment of shunt status.
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- Brain metastases are common in breast cancer patients, leading to a short overall survival of around 6 months despite treatments like external beam radiotherapy (EBRT).
- This study explores a new targeted therapy using lead-212 (212Pb) combined with an anti-VCAM-1 antibody, which effectively targets the early stages of brain metastases.
- Results showed that 212Pb-αVCAM-1 significantly reduced tumor burden and improved overall survival by 29% compared to standard EBRT, without major toxicity observed.